5H-1-Benzothiopyrano[2,3-b]pyridin-5-one
نویسندگان
چکیده
Mol-ecules of the title compound, C(12)H(7)NOS, with one half-mol-ecule in the asymmetric unit, are disordered about a crystallographic centre of inversion. Refinement showed that the C=O group is disordered with the S atom and the N atom is disordered over four positions. Adjacent mol-ecules are connected through C-H⋯O hydrogen bonds and π⋯π inter-actions (centroid-centroid distances of 3.635 and 3.858 Å).
منابع مشابه
7-Nitro-5H-1-benzothiopyrano[2,3-b]pyridin-5-one
In the mol-ecule of the title compound, C(12)H(6)N(2)O(3)S, the central heterocyclic ring is oriented at dihedral angles of 3.25 (6) and 2.28 (7)° with respect to the benzene and pyridine rings, respectively. The dihedral angle between the benzene and pyridine rings is 5.53 (7)°. In the crystal structure, inter-molecular C-H⋯O hydrogen bonds link the mol-ecules into chains.
متن کاملMicrowave assisted synthesis and unusual coupling of some novel pyrido[3,2-f][1,4]thiazepines.
3-Amino-3-thioxopropanamide (1) reacted with ethyl acetoacetate to form 6-hydroxy-4-methyl-2-thioxo-2,3-dihydropyridine-3-carboxamide (2), which reacted with α-haloketones 3 to produce 2,3-disubstituted-8-hydroxy-6-methyl-2H,5H-pyrido[3,2-f]-[1,4]thiazepin-5-ones 4a-c. Benzoylation of 4c led to the formation of the dibenzoate derivative 9. Compounds 4a-c could be prepared stepwise through the f...
متن کاملRupatadine
IN THE TITLE COMPOUND (SYSTEMATIC NAME 8-chloro-11-{1-[(5-methyl-pyridin-3-yl)meth-yl]piperidin-4-yl-idene}-6,11-di-hydro-5H-benzo[5,6]cyclo-hepta-[1,2-b]pyridine), C26H26ClN3, the dihedral angle between the mean planes of the chloro-phenyl and cyclo-hepta-[1,2-b]pyridinyl rings fused to the cyclo-heptane ring is 56.6 (1)°. The mean planes of the cyclo-hepta-[1,2-b]pyridinyl and 5-methyl-pyridi...
متن کاملDiethyl 2-{[(5-oxo-5H-thiochromeno[2,3-b]pyridin-7-yl)amino]methylidene}propanedioate
In the title compound, C(15)H(14)O(2)S, the three fused rings are roughly coplanar, the largest deviation from the mean plane being 0.1285 (13) Å for the S atom. An intra-molecular N-H⋯O hydrogen bond generates an S6 ring. In the crystal, inter-molecular C-H⋯O hydrogen bonds form R(2) (2)(14), R(2) (2)(13) and R(3) (2)(17) ring motifs, building a layer parallel to (100).
متن کاملDesign and One-Pot Synthesis of (1H, 3H) Imidazo[4,5-b] Pyridines: Novel Therapeutic Agents Against M. Tuberculosis
Prevalence to the various biological activities of imidazo[4,5-b] pyridine nucleus has promoted us for an attempt of one pot synthesis of (1H, 3H) imidazo [4,5-b] pyridines (desazopurines) as inhibitors of Lumazine synthase in M. tuberculosis (PDB 2C92). Major advantage of Lumazine synthase enzyme behind consideration as target protein in docking study is its absence in mammalian cell but prese...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 64 شماره
صفحات -
تاریخ انتشار 2008